LETROZOLE COMPARED WITH CLOMPIHENE CITRATE FOR POLYCYSTIC OVARIAN SYNDROME : A SYSTEMATIC REVIEW

According to the Consensus on Management of PCOS, polycystic ovary syndrome, is an endocrine condition that produces oligo-anovulation, clinical and biochemical symptoms hyperandrogenism, distinctive ovarian morphological characteristics ultrasonographic examination. PCOS also associated with a higher risk endometrial cancer. Both hyperandrogenism anovulation are difficult conditions manage. women often have GnRH pulsatility, which in turn causes increased pituitary LH secretion elevated LH/FSH ratio. Granulosa cells responsible for conversion androgens estrogen maturation follicles, while promoting androgen synthesis theca cells. Intraovarian produce atresia later antral stages, although they do boost initial follicle recruitment by increasing preantral early growth. In contrast CC its own, letrozole was shown increase number live births, overall level evidence moderate. There insufficient there difference rate births between plus metformin alone, certainty poor due bias imprecision. When contrasted use itself, potential benefit combination more apparent whose baseline blood insulin or HOMA-IR values were than average. comparison clomiphene citrate, related rates ovulation, pregnancy, successful delivery baby. Despite fact quality data inconsistent, one study recommends over citrate as ovulation induction medicine who infertility PCOS.